We classify drugs by Medical Subject Heading (MeSH) to facilitate users’ browsing. Take a browse "Bortezomib" resistance-related ncRNAs as an example, click “Drug Response” and then select corresponding subcategories, finally select "Bortezomib" option, the browse results will be displayed in the right panel. Click “More” will jump to the result page of corresponding entry (Fig 1).

Fig 1. "Browse" page.

On the “Drug Response” page, you can explore ncRNAs (miRNA, lncRNA, circRNA) associated with drug resistance. Additionally, it offers potential drug combinations for the treatment of resistant cancer.

Explore ncRNAs associated with drug resistance by searching a drug, miRNA, lncRNA, or circRNA names or ID (Drug ID contains PubChem CID, DrugBank ID and NSC Number; miRNA ID is miRBase ID; lncRNA ID contains Ensembl ID and NONCODE GENE ID; circRNA ID is circBase ID). If you want to query a drug, e.g., Bortezomib, you can select “Bortezomib” from the example or directly type the drug name in the search box, then click "Search" button (Fig 2).

Fig 2. Search by "Bortezomib".

The results list all potential entries related to your inputted “Bortezomib”. The basic information of ncRNAs associated with Bortezomib resistance is returned. In the left navigation bar, you can find four dataset sources (Curated, GEO, NCI60 and CCLE) and the number of related entries queried in each source. At the top of result page, there are several filters you can select to restrict the results (Fig 3).

Fig 3. The search result of "Bortezomib".

Click “more”, you can get the detailed information. In Curated source, the detailed information includes “ncRNA Info” (Fig 4), “Drug Info”(Fig 5), “Experiment Info”(Fig 6), “Literature Info” (Fig 7), and “Prediction of sensitizers reversing drug resistance” (Fig 8). Here, we list predicted sensitizers reversing expression of a particular ncRNA associated with drug resistance.

Fig 4. ncRNA info of “H19”.

Fig 5. Drug Info of “Bortezomib”.

Fig 6. Experiment info.

Fig 7. Literature info.

Fig 8. Predicted sensitizers reversing drug resistance.

In GEO source, the detailed information includes “ncRNA Info”, “Drug Info”, “Experiment Info”, “Statistic Info”, as well as “Prediction of sensitizers reversing drug resistance”. “ncRNA Info” and “Drug Info” is similar as that in Curated source, the main difference is that in “Experiment Info”, GEO results contain GSE number, and in “Statistic Info”, GEO results contain log2FC, P-value and FDR (Fig 9).

Fig 9. “Experiment Info” and “Statistic Info” in GEO source.

In NCI60 source, same as GEO source, the detailed information includes the detailed information includes “ncRNA Info”, “Drug Info”, “Experiment Info”, “Statistic Info”, as well as “Prediction of sensitizers reversing drug resistance” (Fig 10).

Fig 10. Detailed result in NCI60 source.

In CCLE source, same as GEO source, the detailed information includes “ncRNA Info”, “Drug Info”, “Experiment Info”, “Statistic Info”, as well as “Prediction of sensitizers reversing drug resistance” (Fig 11).

Fig 11. Detailed result in CCLE source.

Similar to II.

Take search by drug as an example, clicking the “Search” button on the top menu will jump to “Search” page. Type the drug name or drug ID in the search box, click “Search” button (Fig 12).

Fig 12. Search by “Imatinib”.

ncRNADrug will list corresponding results from all resources, both drug response and drug target. In the left navigation bar, you can find five dataset sources (Curated, GEO, CMap, NCI60 and CCLE) and the number of related entries queried in each source. For instance, if you are interested in low-throughput results, you can type “low” in the search box in the upper right corner (Fig 13).

Fig 13. The search result of “Imatinib”.

Click “more”, you can get the detailed information. In Curated source, the detailed information includes “ncRNA Info”, “Drug Info”, “Experiment Info”, “Literature Info”, and “Prediction of sensitizers reversing drug resistance” (Fig 14). Here, we list predicted sensitizers reversing expression of a particular ncRNA associated with drug resistance. For GEO, CMap, NCI60 and CCLE source, please visit IV for a detailed introduction.

Fig 14. Detailed result of “H19”.

Users can submit new information they have found, items with asterisks are required. Click “Reset” button to reset all contents, click “Submit” button to submit (Fig 15). We will check the submission and add it to the database after review.

Fig 15. “Submit” page.

All data were provided for download on the “Download” page. Clicking “txt” or “xlsx” will download the corresponding type of file (Fig 16).

Fig 16. “Download” page.